IgE ELISA Kit

Human Immunoglobulin E (IgE) is a class of antibody primarily involved in allergic reactions and defense against parasitic infections. It is produced by plasma cells and binds to high-affinity receptors (FcεRI) on the surface of mast cells and basophils. Upon exposure to allergens, cross-linking of bound IgE triggers the release of histamine and other inflammatory mediators, leading to classic allergic symptoms such as itching, swelling, and bronchoconstriction. Due to its central role in hypersensitivity reactions, IgE is a key biomarker for diagnosing and monitoring allergic conditions.

In clinical settings, measuring total and allergen-specific IgE levels in blood is critical for diagnosing allergic diseases like asthma, allergic rhinitis, eczema, and food allergies. Specific IgE assays help identify triggers and guide treatment decisions, such as allergen avoidance or immunotherapy. Elevated IgE levels may also support the diagnosis of parasitic infections and certain immunologic disorders, including hyper-IgE syndrome.

In research, IgE serves as a vital tool for studying the mechanisms of allergy and anaphylaxis, evaluating the efficacy of anti-IgE therapies (e.g., omalizumab), and understanding immune regulation. Researchers also use IgE levels to explore genetic predispositions to atopy and to develop novel treatments targeting IgE pathways, which are relevant in both immunology and pharmacology.

This product is manufactured in USA by Eagle Biosciences.