Vasoactive intestinal polypeptide (VIP) is a neuropeptide hormone widely distributed in the central and peripheral nervous systems, as well as the gastrointestinal tract. It functions primarily as a neurotransmitter and vasodilator, promoting smooth muscle relaxation, stimulating secretion of water and electrolytes in the intestines, and modulating immune responses. VIP also plays a role in circadian rhythm regulation and has anti-inflammatory and neuroprotective properties. It binds to specific G-protein coupled receptors (VPAC1 and VPAC2), mediating its diverse physiological effects.
In clinical and research settings, VIP is measured as a biomarker for diagnosing VIPomas—rare neuroendocrine tumors that secrete excessive VIP, leading to a syndrome known as WDHA (watery diarrhea, hypokalemia, and achlorhydria). Elevated plasma VIP levels are key to confirming this diagnosis. Beyond oncology, VIP is studied in autoimmune diseases, inflammatory bowel disease, and neurological disorders due to its immunomodulatory and neurotrophic effects. In research, VIP serves as a valuable tool for understanding neurogastroenterology, neuroimmunology, and potential therapeutic targets for inflammatory and degenerative diseases.
This product is manufactured in USA by Eagle Biosciences.