DHEA Saliva Sensitive ELISA
The DHEA Saliva Sensitive ELISA is For Research Use Only
Size: 1×96 wells
Sensitivity: 1.1 pg/ml
Incubation Time: 2 hours
Sample Type: Human Saliva
Sample Size: 50 µl
Controls Included
Product manufactured in the USA
Assay Background
DHEA is a C19 steroid produced in the adrenal cortex and to a lesser extent gonads. DHEA has a relatively low affinity for sex hormone binding globulin. It circulates in the blood as precursors to estrogens and androgens. DHEA levels are high at birth, low in children, increases through puberty and reaches peak levels just after puberty. In both male and female levels begin to fall as age increases. DHEA is cleared more rapidly than dehydroepiandrosterone sulfate (DHEA-S) in blood. For this reason, the DHEA levels are 100-1000 times lower than DHEA-S in blood. Only 1-10% of DHEA circulating in plasma is in its free or biologically active form. The rest is bound to serum proteins. In saliva, DHEA enters via intracellular mechanisms and reflects the level of Free DHEA in plasma. The physiological role of DHEA has not been clearly defined. Many papers have been published on DHEA showing effects on human health and physiology. DHEA has been reported to have the following effects: anti-diabetes, anti-dementia, anti-obesity, anti-cancer, anti-stress, anti-viral, anti-aging and anti-cardiac disease. DHEA may serve as a marker for hyperandrenalcorticism. Hirsute women and adolescents with acne may have elevated levels of DHEA.
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