CIC C3d ELISA Assay
The CIC C3d ELISA Assay is For Research Use Only
Size: 1×96 wells
Sensitivity: 0.60 mgEq/mL
Dynamic Range: 16 – 64µgEq/ml
Incubation Time: 1.5 hour
Sample Type: Serum, Plasma
Sample Size: 10 µL
Controls Included
Assay Background
The importance of the immunocomplex (CIC) and their relation with several diseases have been object of investigations for many years.The establishment of immunocomplex is a normal protecting process of the immune system. The circulating immunocomplexes are removed from the circulation by means of various cellular, biochemical and enzymatic processes. Key of elimination of many CIC is the activation of the classic way of the complement. In some diseases, of difficult understanding, the immunocomplex can begin the damaging of tissue and organs. In this case the activation of the complement can lead to the anafilotoxine production, stimulation of leukocyte and activation of macrophage and other cells. In some cases of glomerulonephritis, in which the immunocomplex fix to the cellular membranes, it has the destruction of the tissue. Circulating immuno-complexes (CIC) are present in many individuals affections from systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), especially in those affections from vasculitis complications. There are many tests for the determination of CIC, included the test of precipitation with PEG, radial immunodiffusion, and cellular tests like the test of Ray cell.does not exist one procedure to determinate all types of immunocomplex; in commerce some test to determinate fragments of the complex are available (Es. C1q and C3d), that have an important diagnostic meaning.
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Product Developed and Manufactured in Italy by Diametra
