Active Mouse Recombinant SNCA Protein Monomer

$365.00$1,190.00

Type 1 alpha synuclein preformed fibrils seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers.

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SKU: SPR-323 Categories: ,

Active Mouse Recombinant SNCA Protein Monomer

For Research Use Only

Specificity: ~14.46 kDa
Species: Mouse
Expression System: E. coli
Buffer: PBS
Storage Temperature: -80ºC

Product manufactured in Canada by StressMarq.

Additional Information

Assay Background


Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease. Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

Comparative Protein Graph


Manual

Product Manual