Active Human Recombinant Tau441 (2N4R) Wild-Type Protein Monomer

$535.00$1,660.00

The Active Human Recombinant Tau441 (2N4R) Wild-Type Protein Monomer is intended for research use only and not for use in diagnostic or clinical procedures.

SKU: SPR-479 Categories: , ,

Active Human Recombinant Tau441 (2N4R) Wild-Type Protein Monomer

The Active Human Tau Wild-Type Protein Monomer is For Research Use Only

Specificity: N/A
Species: Human
Expression System: E. coli
Buffer: 10 mM HEPES, 100 mM NaCl pH 7.4
Storage Temperature: -80ºC
Alternative Names: Active tau monomer, active tau protein monomer, active tau protein, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Monomer, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid tau protein fragment, Truncated Tau Protein, MAPT DeltaK280, ΔK280 tau, K18 delta K280 tau, truncated ΔK280 tau

Product manufactured in Canada by StressMarq.


Scientific Background

Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). The ΔK280 mutation is associated with frontotemporal dementia and promotes fibrillization into paired helical filaments (PHFs) in the absence of heparin and other inducers (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5).


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Package Inserts


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