17OH Progesterone Saliva ELISA Assay
The 17OH Progesterone Saliva ELISA Assay is For Research Use Only
Size: 1×96 wells
Sensitivity: 4.9 pg/ml
Dynamic Range: 0 – 1600 pg/ml
Incubation Time: 1.5 hour
Sample Type: Saliva
Sample Size: 50 µL
17OH Progesterone (17α-OHP, 17-hydroxy-4-Pregnene-3,20-dione) is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans.
As with cortisol, serum 17α -OHP levels normally have an ACTH-dependent diurnal variation, with peak levels in the morning and a nadir at night. In addition, ovarian production of 17α -OHP increases during the luteal phase of the menstrual cycle, leading to serum levels which are several-fold higher than during the follicular phase. The level of 17OHP in saliva (pg/mL) is significantly lower than levels in the general circulation (ng/mL). Progesterone appears to prevent endometrial cancer by regulating the effects of estrogen. Measurement of circulating 17α -OHP levels is a standard tool for clinical assessment of 21-hydroxylase deficiency, the most common cause of congenital adrenal hyperplasia. Due to the decreased activity of 21-hydroxylase, 17α -OHP cannot be efficiently converted to cortisol and, instead, accumulates in large amounts and is shunted into the androgen biosynthetic pathway. 17α -OHP levels are useful in monitoring steroid replacement therapy.