Glutathione S-transferase alpha (GST Alpha) is a phase II detoxification enzyme predominantly expressed in the liver. It plays a crucial role in cellular defense by catalyzing the conjugation of glutathione to electrophilic compounds, facilitating their detoxification and excretion. In rats, GST Alpha is widely used as a biomarker of hepatic function and xenobiotic metabolism because its expression and activity are sensitive to chemical exposure, oxidative stress, and liver injury. Alterations in GST Alpha levels can reflect both acute and chronic hepatotoxicity, making it a valuable indicator in toxicology studies.
The rat GST Alpha ELISA allows for sensitive and specific quantification of GST Alpha protein levels in serum, plasma, or tissue homogenates. In research, this assay is commonly used to evaluate liver injury caused by drugs, environmental toxins, or experimental compounds, providing insight into hepatocellular damage and detoxification responses. It is also employed in studies of oxidative stress, metabolic regulation, and disease models where liver function is compromised.
In a clinical or translational context, measuring GST Alpha can help monitor liver health and predict drug-induced hepatotoxicity. Although primarily a preclinical tool, findings from rat GST Alpha studies can inform human risk assessment and therapeutic safety, supporting the development of safer pharmaceuticals and environmental health strategies. Its ability to serve as an early and sensitive marker of hepatocellular stress makes it a practical choice for both experimental and applied toxicological studies.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 1.473 ng/mL |
| Dynamic Range | 3.125 ng/mL – 100 ng/mL |
| Incubation Time | 3 hours 10 minutes |
| Sample Type | Serum, plasma |
| Storage | 2-8°C |
| Alternative Names | Glutathione S-Transferase A1, GSTA1, GST A1-1, and Alpha-Class Glutathione S-Transferase. |