Rat Immunoglobulin E (IgE) is an antibody isotype primarily involved in allergic responses and defense against parasitic infections. Produced by B cells in response to allergens or certain pathogens, IgE binds to high-affinity receptors on mast cells and basophils, triggering the release of histamine and other inflammatory mediators. In laboratory settings, measuring IgE levels in rats provides insights into immune system activation, allergic sensitization, and the mechanisms underlying hypersensitivity reactions. Because IgE is tightly regulated and typically present at low concentrations in normal serum, sensitive detection methods such as ELISA are essential for accurate quantification.
The Rat IgE ELISA is a widely used immunoassay designed to measure IgE concentrations in rat serum, plasma, or other biological fluids. In research, it allows investigators to evaluate allergic responses, monitor immunotherapy effects, and study the role of IgE in models of asthma, atopic dermatitis, and parasitic infections. It also enables comparison of immune responses under different experimental conditions, such as drug treatments or genetic modifications.
While Rat IgE ELISAs are primarily research tools, they also have applications in preclinical studies that inform human health, particularly in evaluating potential anti-allergic or immunomodulatory therapies. By providing quantitative data on IgE levels, these assays help bridge mechanistic studies in animal models with translational insights relevant to human allergic diseases, aiding in both safety and efficacy assessments during drug development.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 0.213 ng/mL |
| Dynamic Range | 1 ng/mL – 32 ng/mL |
| Incubation Time | 2 hours 10 minutes |
| Sample Type | Serum, plasma |
| Storage | 2-8°C |
| Alternative Names | IgE antibody, epsilon immunoglobulin, or γE-globulin. |