Rat Immunoglobulin M (IgM) is a high-molecular-weight antibody and the first class of immunoglobulin produced during an initial immune response. It plays a critical role in the recognition and neutralization of pathogens, forming pentameric structures that efficiently bind antigens and activate the complement system. As a primary responder in humoral immunity, IgM levels in serum or plasma can reflect early-stage immune responses, making it a valuable biomarker in immunology studies. In rats, IgM is commonly measured to investigate immune function, vaccine responses, or the effects of immunomodulatory treatments.
The rat IgM ELISA is a sensitive immunoassay designed to quantitatively detect IgM in serum, plasma, or cell culture supernatants. In research settings, this assay is widely used to evaluate humoral immune responses in experimental models, monitor B cell activation, and study autoimmune or infectious disease mechanisms. It allows researchers to track temporal changes in IgM production following immunization or infection, providing insights into immune dynamics.
Although primarily a research tool, rat IgM measurement can also support translational studies that model human diseases or therapeutic interventions. By assessing IgM levels, researchers can evaluate the efficacy of vaccines, biologics, or immunotherapies in preclinical rat models, and better understand the early immune response patterns that may inform clinical strategies.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 2.841 ng/mL |
| Dynamic Range | 31.25 ng/mL – 1000 ng/mL |
| Incubation Time | 1 hour 10 minutes |
| Sample Type | Serum, plasma |
| Storage | 2-8°C |
| Alternative Names | Immunoglobulin M, macroglobulin, and pentameric antibody. |