Retinol Binding Protein (RBP) is a small plasma protein primarily synthesized by the liver and responsible for the transport of vitamin A (retinol) from the liver to peripheral tissues. In mice, as in humans, RBP plays a key role in vitamin A homeostasis, visual function, and cellular differentiation. Changes in circulating RBP levels can indicate alterations in nutritional status, liver function, kidney function, and metabolic regulation, making it a valuable biomarker in both research and preclinical studies.
In research settings, mouse RBP is commonly used to study vitamin A metabolism, nutritional interventions, and metabolic disorders. It serves as a marker for hepatic function, protein synthesis, and retinoid transport, helping researchers investigate the effects of diet, disease, or therapeutic interventions on vitamin A dynamics. RBP levels are also monitored in models of renal disease, as impaired kidney function can alter RBP clearance, providing insight into systemic metabolic regulation.
In clinical and translational contexts, measuring mouse RBP helps model human conditions such as vitamin A deficiency, liver disease, obesity-related metabolic disorders, and kidney dysfunction. Circulating RBP can indicate nutritional status, early renal impairment, or metabolic imbalance, supporting the evaluation of therapeutics targeting metabolic or liver-related diseases. RBP measurement in mice thus provides a bridge between preclinical studies and potential human clinical applications in nutrition, endocrinology, and nephrology.
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