Total complement functional screen ELISA Kit

The Total Complement Functional Screen is a laboratory assay designed to evaluate the overall functionality of the complement system, a key component of innate immunity. The complement system consists of a series of plasma proteins that, when activated, mediate pathogen clearance, inflammation, and immune complex removal. Total complement assays, such as the CH50 (classical pathway) and AH50 (alternative pathway) tests, measure the ability of a patient’s serum to lyse standardized target cells (commonly sheep or rabbit red blood cells) through activation of the respective complement pathways. These assays provide a global view of complement activity, rather than quantifying individual complement proteins, making them particularly useful for detecting functional deficiencies or dysregulation.
In a research setting, total complement functional screens are often used to study immune system dynamics, monitor the impact of experimental treatments on complement activation, or investigate pathophysiological mechanisms in autoimmune diseases, infections, or inflammatory conditions. By assessing complement functionality, researchers can correlate complement activity with disease progression, immune response efficiency, or therapeutic outcomes in preclinical models.
In a clinical setting, these assays are commonly used to diagnose complement deficiencies (such as C1q, C2, C3 deficiencies), monitor autoimmune diseases like systemic lupus erythematosus (SLE), or detect excessive complement activation associated with conditions like atypical hemolytic uremic syndrome (aHUS). Total complement functional screens can guide treatment decisions, such as complement-targeted therapies, and are often used alongside specific complement protein measurements for a comprehensive evaluation of patient immune status.

This product is manufactured in Sweden by Svar Life Sciences.