Porcine Immunoglobulin M (IgM) is the first antibody isotype produced during a primary immune response and plays a critical role in early defense against pathogens. Structurally, IgM exists primarily as a pentamer, giving it high avidity for antigens and potent complement-activating capability. In pigs, IgM is essential for initial pathogen neutralization and the activation of downstream adaptive immune responses. The Porcine IgM ELISA (Enzyme-Linked Immunosorbent Assay) is a quantitative immunoassay designed to measure total or antigen-specific IgM levels in serum, plasma, colostrum, or other biological samples. The assay uses species-specific capture and detection antibodies to generate a colorimetric or fluorescent signal proportional to IgM concentration.
In research, the Porcine IgM ELISA is widely used to study primary humoral immune responses in swine vaccination, infection, or immunomodulation experiments. Measuring IgM provides insight into the early stages of B-cell activation before class-switching to IgG, helping researchers assess immune competence and the kinetics of antibody production. It is also valuable in studies of neonatal immunity, where piglets rely on maternal IgM and IgG for protection, and in disease modeling, including bacterial, viral, and parasitic infections. Researchers can use IgM levels to evaluate vaccine efficacy, immune adjuvants, or interventions aimed at enhancing early immune responses.
Clinically, IgM serves as a biomarker of acute infection or recent immune activation in pigs, providing veterinarians with a tool to monitor herd health, early-stage infections, or vaccine response. In translational research, porcine IgM studies are relevant because pigs share immunological and physiological similarities with humans, making them a valuable model for evaluating vaccine candidates, immune therapies, and infectious disease interventions. In summary, the Porcine IgM ELISA is a quantitative biomarker assay critical for assessing early humoral immune responses, with applications spanning veterinary diagnostics, immunology research, and preclinical translational studies.
This product is manufactured in USA by Eagle Biosciences.