Dopamine is a critical neurotransmitter in mice, functioning in the central nervous system to regulate motor control, reward, motivation, learning, and mood. It is synthesized from the amino acid tyrosine through a pathway involving the enzymes tyrosine hydroxylase and DOPA decarboxylase, primarily in dopaminergic neurons located in regions such as the substantia nigra, ventral tegmental area, and hypothalamus. As a biomarker, dopamine reflects the functional state of dopaminergic pathways, making it useful for studying neurochemical signaling, behavior, and neurodegenerative processes. Dopamine levels in mice can be measured in brain tissue, cerebrospinal fluid, or extracellular fluid using techniques such as high-performance liquid chromatography (HPLC) or microdialysis.
In research, mouse dopamine serves as a key biomarker for studying neurological and psychiatric disorders, including Parkinson’s disease, schizophrenia, depression, and addiction. Researchers use dopamine measurements to investigate the effects of genetic modifications, pharmacological treatments, or environmental interventions on dopaminergic signaling. Mouse models allow precise manipulation of dopamine pathways to understand their role in motor function, reward processing, and cognitive behaviors. Additionally, monitoring dopamine dynamics helps elucidate the mechanisms of neurodegeneration, stress response, and drug action, making it an essential biomarker for translational studies that bridge basic neuroscience with potential therapeutic applications.
This product is manufactured in Germany by DLD Diagnostika.
| Size | 1 x 96 Well |
| Sensitivity | 5.9 pg/mL |
| Dynamic Range | 0.3 – 100 ng/mL |
| Incubation Time | overnight |
| Sample Type | Plasma, Cell Culture, Tissue Homogenates, Biological Fluids |
| Storage | 2-8°C |
| Alternative Names | 3,4-dihydroxyphenethylamine, DA, a catecholamine neurotransmitter, or dihydroxyphenylethylamine. |
